Jayne Raper, Professor of Biological Sciences
- BSc, 1982, University of Newcastle Upon Tyne, UK.
- Ph.D., 1989,University of Cambridge, UK.
- Post Doc. 1989-1993 Johns Hopkins School of Medicine, Baltimore
- Post Doc 1993-1995 The de Duve Institute of International Cellular Pathology, Belgium.
- Trypanosome lytic factors, antimicrobial high density lipoproteins and their role in innate immunity
Our laboratory works on trypanosome lytic factors (TLFs), which are antimicrobial high-density lipoproteins that contribute to primate innate immunity. TLFs are characterized by their ability to kill African trypanosomes, which are extracellular protozoon parasites. The unique protein components of TLF are hemoglobin binding protein, Haptoglobin-related protein (Hpr) and a pore forming protein, apolipoprotein L-I (apoL-I).
- Lukeš J, Raper J., (2010) Prophylactic antiparasitic transgenesis for human parasitic disease? Mol Ther. 18(10):1745-1747.
- Thomson, R., Molina-Portela, M.P., Mott, H., Carrington, M., and Raper, J. (2009) Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates animal and human infective African trypanosomes. Proc. Nat. Acad. Sci. 106:19509-195147
- Thomson, R., Samanovic, M. and Raper, J. (2009) Activity of Trypanosome Lytic Factor: a novel component of innate immunity. Future Microbiology 4(7): 789-796
- Bettiol, E., Samanovic, M., Murkin, A. S., Raper, J., Buckner, F. and Rodriguez, A. (2009) Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. PLoS Neglected Tropical Diseases Feb;3(2):e384.
- Samanovic, M., Molina-Portela, M.P., Chessler, A-D.C., Burleigh, B.A., and Raper, J. (2009) Trypanosome Lytic Factor, an Antimicrobial High Density Lipoprotein, Ameliorates Leishmania Infection. PLoS Pathogens Jan;5(1):e1000276.
- Molina Portela, M.P., Samanovic, M., and Raper, J. (2008) Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. J. Exp. Med. 205: 1721-1728.