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Full List of Publications:

  • M.J. Turner, M.L. Cardoso de Almedia, A.M. Gurnett, J. Raper and J. Ward (1985) Biosynthesis, attachment and release of variant surface glycoproteins of the African trypanosome. Curr. Top. Microbiol. Immun. 177, 23-55
  • A.M. Gurnett, J. Raper and M.J. Turner (1986) Solution properties of the variant surface glycoprotein of T.brucei Mol. Biochem. Parasitol. 18, 141-153
  • A.M. Gurnett, J. Raper, J. Ward and M.J. Turner (1986) Purification and characterisation of membrane form variant surface glycoproteins of T.brucei. Mol. Biochem. Parasitol. 20, 1-13
  • J. Raper  (1989) G protein function in T. b. brucei.  Ph.D.Thesis. Cambridge.
  • W.J. Masterson, J. Raper, T. L. Doering, G.W. Hart and P.T. Englund (1990).  Fatty acid remodelling:  A novel reaction sequence in the biosynthesis of trypanosome glycosyl phosphatidylinositol membrane anchors. Cell, 62, 73-80
  • K. Mensa-Wilmot, T.L. Doering, J. Raper, L.U. Buxbaum, G.W. Hart and P.T. Englund. Glycosyl phosphatidylinositol membranes anchors in African trypanosomes (1991).  In: Biology of Parasitism (C.C.Wang, ed.), AAAS Press, Washington, D.C.  pp 43-54
  • T.L.  Doering, J. Raper,  L.U. Buxbaum,  J.I. Gordon,  S.P. Adams,  G.W. Hart and P.T. Englund (1991). An analogue of myristic acid with selective toxicity for African trypanosomes. Science, 252, 1851-1854
  • T. L.  Doering, J. Raper,  L.U. Buxbaum,  G.W. Hart and  P.T. Englund (1991).  Biosynthesis of glycosyl phosphatidylinositol protein anchors.  Methods: A companion to Methods in Enzymology, 1(3), 288-296
  • J. Raper, Doering, T.L.,  L.U. Buxbaum,  and  P.T. Englund, (1993).  Glycosylphosphatidylinositols in Trypanosma brucei.  Exp. Parasitol., 76, 216-220.
  •  N. Heise, J. Raper, and M.L. Cardoso de Almeida. (1994) Characterization of a phospholipase C resistant inositol containing glycolipid from Trypanosoma Cruzi.  Brazilian J. Med. Biol. Res., 27, 233-238
  • M. Prado-Figuroa, J. Raper, and F. R. Opperdoes. (1994).  Possible location of dolichol-dependent mannosyltransferase of Trypanosma brucei to the endoplasmic reticulum.  Mol. Biochem. Parasitol., 63, 255-264L.U.
  • Buxbaum, J. Raper, F.R. Opperdoes and P.T. Englund. (1994)  Myristate exchange: a second glycosyl phosphatidyl inositol myristoylation reaction in African trypanosomes. J. Biol. Chem.  269, 30212-30220
  • P. Bastin, J. Raper, A. Stephan, J.-M. Saint-Remy, F.R. Opperdoes, and P. J. Courtoy.  (1995) An Mr 145 kDa LDL binding protein is conserved throughout the kinetoplastida order. Mol. Biochem. Parasitol. 76, 43-56
  • N. Heise, J. Raper, L.U. Buxbaum, T.M.S. Peranovich and M.L.C. de Almeida. (1996) Identification of complete precursors for the glycosylphosphatidylinositol protein anchors of Trypanosoma cruzi J. Biol. Chem. 271, 16877-16887
  • J. Raper, V. Nussenzweig and S. Tomlinson.  (1996) Lack of correlation between haptoglobin concentration and trypanolytic activity of normal human serum. Mol. Biochem. Parasitol. 76, 337-338
  •  J. Raper, V. Nussenzweig and S. Tomlinson. (1996) The main lytic factor of Trypanosoma. b. brucei in normal human serum is not high density lipoprotein.  J. Exp. Med.  183, 1023-1030
  • S. Tomlinson and J. Raper. (1996) The lysis of Trypanosoma brucei brucei by human serum. Nature Biotechnology. 14, 717-721
  • S. Tomlinson, M Muranjan, V. Nussenzweig, and J. Raper. (1997)  Haptoglobin-related protein and apolipoprotein A-I are components of the two trypanolytic factors in human serum.  Mol. Biochem. Parasitol.  86, 117-120
  • S. Tomlinson and J. Raper. (1998) Natural human immunity to trypanosomes. Parasitol. Today. 14, 354-359
  • J. Raper, R. Fung, G. Ghiso, V. Nussenzweig and S. Tomlinson. (1999) The characterisation of a novel trypanosome lytic factor in human serum. Infection and Immunity.  67, 1910-1916
  • M. P. Molina Portela, J. Raper and S. Tomlinson. (2000) An Investigation into the Mechanism of Trypanosome Lysis by Human Serum Factors Mol. Biochem. Parasitol. 110. 273-282
  • J. Raper, M. P. Molina Portela, E.Lugli, U. Frevert, S. Tomlinson. (2001) Trypanosome lytic factors: Novel mediators of Innate Human Immunity. Current Opinions in Microbiology. 4, 402-408
  • J. Raper, M. P. Molina Portela, M. R. Redpath, S. Tomlinson, E. Lugli, H. Green (2002) Natural Immunity to African Trypanosomiasis: Trypanosome lytic factors and the blood incubation infectivity test. Molecular epidemiology and molecular diagnosis of parasitic diseases. Trans. R. Soc. Trop. Med. Hyg. 96, 2-5
  • H. Green, M.P. Molina Portela, E. St. Jean, E. Lugli, J. Raper (2003) Evidence for a lipoprotein scavenger receptor in Trypanosoma brucei brucei. J. Biol. Chem. 278, 422-427
  • Lugli EB, Pouliot M, Portela Mdel P, Loomis MR, Raper J (2004) Characterization of primate trypanosome lytic factors. Mol. Biochem. Parasitol. 138, 9-20.
  • M.P. Molina Portela, E.B. Lugli, E Recio-Pinto, J. Raper (2005) Trypanosome Lytic Factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Mol. Biochem. Parasitol. 144, 218-26
  • M.P. Molina Portela, M. Samanovic and J. Raper (2008) Distinct roles of apolipoprotein components within the trypanosome lytic factor complex revealed in a novel transgenic mouse model. J. Exp. Med. 205, 1721-1728
  • *Faculty of 1000 Biology: evaluations for Molina-Portela MP et al J Exp Med 2008 Aug 4 205     (8):1721-8 http://www.f1000biology.com/article/id/1120034/evaluation
  • Special commentary, In this Issue: Triple punch against trypanosomes by Hema Bashyam    http://jem.rupress.org/cgi/content/full/205/8/1716
  • R. Thomson, P. Molina-Portela, J. Raper (2008) Identification and Cloning of Baboon proteins which Kill Human Infective African Trypanosomes in vivo. Am. J. Trop. Med. Hyg. 79, 350-390
  • M. Samanovic, M.P. Molina-Portela, A-D.C.Chessler, B.A.Burleigh, J. Raper (2009) Trypanosome Lytic Factor, an Antimicrobial High Density Lipoprotein, Ameliorates Leishmania Infection. PLoS Pathogens Jan;5(1):e1000276
  • E. Bettiol, M. Samanovic, A. S. Murkin, J. Raper, F. Buckner and A. Rodriguez (2009) Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening. PLoS Neglected Tropical Diseases Feb;3(2):e384
  • R. Thomson, M. Samanovic, J. Raper (2009) The activity of Trypanosome Lytic Factor- a novel component of innate immunity. Future Microbiology 4(7): 789-796
  • R. Thomson, M.P. Molina-Portela, H. Mott, M. Carrington, J. Raper (2009) Hydrodynamic gene delivery of baboon TLF eradicates animal and human infective African trypanosomes. Proc. Nat. Acad. Sci. 106: 19509-19514
  • LukeŇ° J, Raper J., (2010) Prophylactic antiparasitic transgenesis for human parasitic disease? Mol Ther. 18(10):1745-1747.
  • Capewell, P*. Veitch NJ, Turner CMR, Raper, J, Berriman, M, Hadjuk, S, Macleod, A. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1. PLoS Neglected Tropical Diseases Sep; 5(9):e1287
  • Frevert U, Movila A, Nikolskaia OV, Raper J, Mackey ZB, et al. (2012) Early Invasion of Brain Parenchyma by African Trypanosomes. PLoS ONE 7(8):e43913.
  • Structure of the trypanosome haptoglobin-hemoglobin receptor and implications for nutrient uptake and innate immunity. Higgins MK, Tkachenko O, Brown A, Reed J, Raper J, Carrington M. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1905-10.
  • Parasitology: Molecular one-upmanship.Raper J, Friedman DJ. Nature. 2013 Sep 19;501(7467):322-3. doi: 10.1038/501322a. PMID: 24048062
  • Evolution of the primate trypanolytic factor APOL1.Thomson R, Genovese G, Canon C#, Kovacsics D, Higgins MK, Carrington M, Winkler CA, Kopp J, Rotimi C, Adeyemo A, Doumatey A, Ayodo G, Alper SL, Pollak MR, Friedman DJ, Raper J. Proc Natl Acad Sci U S A. 2014 May 20;111(20) PMID: 24808134
  • Transient expression of proteins by hydrodynamic gene delivery in mice. Kovacsics D, Raper J. J Vis Exp. 2014 May 5;(87).PMID: 24837006
  • BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Heneghan JF, Vandorpe DH, Shmukler BE, Giovinazzo JA*, Raper J, Friedman DJ, Pollak MR, Alper SL. Am J Physiol Cell Physiol. 2015 Sep 1;309(5):C332-47. doi: 10.1152/ajpcell.00142.2015. PMID: 26108665


Media publications:

  • 2000    New York Times Magazine June 4, -interviewed and published in “Triumph of     the Brainiac (The Smart Set)” -an article on Intel Science Talent Search semi-    finalists at Midwood High School in Brooklyn
  • 2007    New Scientist August 25, -interviewed and published in “Ending the     nightmare” -an article on African sleeping sickness and trypanosome lytic     factors.
  • 2011        Nature Medicine January Vol 17 (1) 14-17-interviewed and published in     “Putting Sleeping Sickness to bed”-an article on African sleeping sickness       and therapeutic strategies.
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Last Updated ( Friday, 13 November 2015 15:26 )